Since the 1990s, the rapid expansion of China’s textiles and clothing enterprises to Cambodia has been closely linked to the phenomenon of industrial clustering of textiles and clothing firms at the Yangtze River Delta, Pearl River Delta and Bohai Rim. The report adopts the case study approach to examine the pattern and features of overseas foreign direct investment (OFDI) of textile and clothing firms in Zhejiang province and Jiangsu province of the Yangtze River Delta to the least developed countries (LDCs) in the Asian and Pacific region, particularly Cambodia, and make the corresponding policy suggestions on the sustainability of South-South investment and cooperation.